Direct effect of histamine on arterial and venous resistance in isolated dog hindlimb

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Abstract
Measurements of femoral and saphenous venous pressures, peripheral venous pressures in both digital and muscle veins, arterial pressure, leg weight, and saphenous and femoral venous outflows were made under conditions of constant flow and constant pressure perfusion during infusion of histamine diphosphate in the isolated dog hindlimb. The direct effect of intra-arterially administered histamine is to produce arteriolar and venous dilation. Infusion of histamine at rates of 1.0-5. 0 [mu]gAg/min. results in a significant shift in blood flow from muscle to the skin segment of the hindlimb, whereas infusions of 20-60 [mu]g/kg/min. result in a shift of blood flow from skin to muscle thus indicating that histamine causes disproportionate alterations in arteriolar caliber in the 2 beds. Capillary filtration is not affected by low doses but is measurably increased by high doses of histamine, and the increased rate of filtration may be the result of an increase in capillary membrane permeability. In the dog, the edema which occurs during histamine administration does not result from a direct action by histamine to cause venous constriction.

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