Preferential VH/Vλ pairings occur in the available B cell repertoire of adult BALB/c mice
- 1 April 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 4 (4) , 501-507
- https://doi.org/10.1093/intimm/4.4.501
Abstract
To gain insights into the composition of the B cell repertoire, we have investigated VH gene family expression associated with individual light chains. For this purpose, we have examined the use of 12 VH gene families in a large collection of hybridomas expressing one of the four γ light chains (γ1 (V1J1), γ2 (V2J2 and VxJ2) and γ3 (V1J3)]. Our results show that the distribution of the VH families Is very different from one X subtype to another. This suggests that a few substitutions between VL regions are sufficient to generate very different associated repertoires by strong selection mechanisms. Moreover, we assume that the global VH expression pattern is not random but rather composed of many preferential Vh/VL associations.Keywords
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