Histochemical and Biochemical Studies on Leukocyte Alkaline Phosphatase Activity
Open Access
- 1 November 1955
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 10 (11) , 1120-1131
- https://doi.org/10.1182/blood.v10.11.1120.1120
Abstract
(1) In a large series of individuals alkaline phosphatase activity in the leukocyte was studied by biochemical and histochemical methods. (2) The value of combined histochemical and biochemical measurements is demonstrated in this report. (3) In chronic myelogenous leukemia the neutrophil contain very little alkaline phosphatase activity while in myeloid metaplasia and pyogenic infections morphologically similar cells exhibit a great increase in this enzyme. (4) Various factors which might influence alkaline phosphatase activity in See PDF for Figure See PDF for Table leukocytes were investigated and it was found that on incubation in serum or saline the cell alkaline phosphatase activity increased. However, this in vitro rise was unrelated to the source of the serum menstrum.Keywords
This publication has 3 references indexed in Scilit:
- Biochemical Studies in Chronic Myelocytic Leukemia, Polycythemia Vera and Other Idiopathic Myeloproliferative DisordersBlood, 1952
- ACID AND ALKALINE PHOSPHATASE IN WHITE CELLS DATA FOR THE LYMPHOCYTE AND THE POLYMORPHONUCLEAR LEUKOCYTE OF MAN AND THE RABBITBlood, 1950
- ALKALINE PHOSPHATASE ACTIVITY IN NORMAL AND ABNORMAL HUMAN BLOOD AND BONE MARROW CELLS1946