Elevation of CRABP-I in the Cerebrospinal Fluid of Patients With Moyamoya Disease
- 1 December 2003
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 34 (12) , 2835-2841
- https://doi.org/10.1161/01.str.0000100159.43123.d7
Abstract
Background and Purpose— The etiology of moyamoya disease (MMD) remains obscure. This study was undertaken to identify specific proteins associated with the pathogenesis of MMD. Methods— We studied cerebrospinal fluid (CSF) from 20 patients with angiographically confirmed MMD (4 boys and 16 girls; age range, 3 to 13 years; mean, 7.5 years) and 4 control patients with cerebral palsy who underwent selective dorsal rhizotomy (2 boys and 2 girls; age range, 5 to 10 years; mean, 7.3 years). CSF proteins were analyzed by 2-dimensional polyacrylamide gel electrophoresis, and protein identification was performed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The presence of specific CSF protein in patients with MMD was confirmed by Western blotting. In addition, cerebral CSF was also tested in 7 patients who had other brain diseases but no MMD (2 boys and 5 girls; age range, 1 to 12 years; mean, 6.9 years). Results— We identified 1 polypeptide spot (Mr of 13 to 15 kDa and isoelect...Keywords
This publication has 21 references indexed in Scilit:
- Retinoic acid suppresses intimal hyperplasia and prevents vessel remodeling following arterial injuryCardiovascular Surgery, 1999
- Role of transforming growth factor—β1 in the pathogenesis of moyamoya diseaseJournal of Neurosurgery, 1998
- Retinoic acid uses divergent mechanisms to activate or suppress mitogenesis in rat aortic smooth muscle cells.Journal of Clinical Investigation, 1998
- Elevation of Cerebrospinal Fluid Levels of Basic Fibroblast Growth Factor in Moyamoya and Central Nervous System DisordersPediatric Neurosurgery, 1997
- Immunohistochemical Reactions for Fibroblast Growth Factor Receptor in Arteries of Patients with Moyamoya DiseaseNeurosurgery, 1994
- Kinetics of 125I‐PDGF binding and down‐regulation of PDGF receptor in arterial smooth muscle cells derived from patients with moyamoya diseaseJournal of Cellular Physiology, 1993
- SWISS‐2DPAGE: A database of two‐dimensional gel electrophoresis imagesElectrophoresis, 1993
- Possible roles of basic fibroblast growth factor in the pathogenesis of moyamoya disease: an immunohistochemical studyJournal of Neurosurgery, 1991
- Altered cellular responses to serum mitogens, including platelet‐derived growth factor, in cultured smooth muscle cells derived from arteries of patients with moyamoya diseaseJournal of Cellular Physiology, 1991
- Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells.The Journal of cell biology, 1991