Synthesis of lanosterol analogs with lengthened side chains and their effects on cholesterol biosynthesis from lanosterol.
- 1 January 1984
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 32 (5) , 1912-1918
- https://doi.org/10.1248/cpb.32.1912
Abstract
Starting from 3.beta.-acetoxy-25,26,27-trinorlanost-8-en-24-al, 8 lanosterol analogs (10-17) with longer side chains than that of lanosterol were synthesized by Wittig reaction followed by catalytic hydrogenation. Cholesterol biosynthesis was examined in rat hepatic subcellular preparation (S10) incubated with [24-3H]-lanosterol in the presence of each of the 8 lanosterol analogs. Some of the analogs (10 and 12) caused slight inhibition, but 16 and 17 showed no inhibitory effect. The structure-inhibitory activity relationship of lanosterol analogs on cholesterol biosynthesis from lanosterol is discussed.This publication has 1 reference indexed in Scilit:
- Effects of lanosterol analogs on cholesterol biosynthesis from lanosterol.CHEMICAL & PHARMACEUTICAL BULLETIN, 1981