ERYTHROCYTE ACETYLCHOLINESTERASE ACTIVITY IN ABO HEMOLYTIC DISEASE OF THE NEWBORN
- 1 February 1964
- journal article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 33 (2) , 205-211
- https://doi.org/10.1542/peds.33.2.205
Abstract
Erythrocyte AChE is reduced in ABO hemolytic disease of the newborn. This enzyme alteration is not present in all infants with ABO disease, nor in all erythrocytes of affected infants. Treatment of erythrocytes with anti A or B antibodies has not resulted in AChE decrease, but such decrease regularly follows erythrocyte treatment by proteolytic enzymes. While AChE is normal in Rh hemolytic disease of the newborn it is decreased in one infant exhibiting features of both ABO and Rh disease. The measurement of erythrocyte AChE activity provides a simple colorimetric test to confirm the diagnosis of ABO hemolytic disease of the newborn. The reduced activity of this surface located erythrocyte enzyme in ABO disease and in paroxysmal nocturnal hemoglobinuria suggests that a similar extracorpuscular mechanism could be involved in both conditions. The demonstration of an enzymatic abnormality in erythrocytes associated with an immune hemolytic anemia may yield a model system for further study of cellular reactions in immune diseases.Keywords
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