EFFECT OF COMMON PROTECTIVE ANTIGEN VACCINATION TO PROTECT MINK FROM CHALLENGE EXPOSURE WITH PSEUDOMONAS-AERUGINOSA

  • 1 January 1976
    • journal article
    • research article
    • Vol. 37  (12) , 1441-1444
Abstract
The protein portion of endotoxin (OEP), or common antigen of P. aeruginosa prepared from strain N10 of P. aeruginosa, was examined as a possible vaccine against this organism in mink. Mink were given OEP vaccine and intranasally [i.n.] challenge exposed. They survived after this exposure with 4 LD50 doses of strain NC-5 (protease negative, elastase negative) or with 160 LD50 doses of strain 5 (protease positive, elastase positive). Strain NC-5 belonged to type 5 and strain 5 belonged to type 8 (according to the serotyping method of Homma). Strain N10, the source of OEP, belonged to serotype 5. Thus, the mink vaccinated with OEP vaccine were able to stand challenge exposure to homologous and heterologous serotype strains. More mink given OEP vaccine survived the challenge exposure by i.n. spraying with virulent strain 5 than did those in the nonvaccinated control group, with a significant difference. When the surviving mink of the vaccinated group were rechallenge exposed with 300 or 3000 LD50 doses of the same strain 1 mo. later, most of them survived.

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