A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
- 27 December 1990
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 348 (6303) , 699-704
- https://doi.org/10.1038/348699a0
Abstract
A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.Keywords
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