In Vitro Antibacterial Activity and β-Lactamase Stability of SCE-129, a New Cephalosporin

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Abstract
SCE-129 [3-4-carbamoyl-1-pyridiniomethyl-7β- ( d -α-sulfophenylacetamido)-ceph-3-em-4-carboxylate] is a cephalosporin that inhibits Pseudomonas aeruginosa and Staphylococcus aureus . SCE-129 is tenfold more active than carbenicillin in inhibiting P. aeruginosa . SCE-129 has poor activity against Enterobacteriaceae compared with other cephalosporins and is 16-fold less active than the cephalosporins against streptococci. The activity of SCE-129 does not correlate with β-lactamase stability, although SCE-129 is resistant to hydrolysis by gram-positive and gram-negative bacteria. The compound does not inhibit the hydrolysis of other cephalosporins. Although SCE-129 acts synergistically with gentamicin to inhibit some Pseudomonas , this cannot be predicted based on knowledge of resistance to one or more compounds.