EFFECT OF INCREASED INTRAVASCULAR PRESSURE ON THE BLOOD-BRAIN BARRIER TO PROTEIN IN DOGS

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Abstract
In a previous study it was suggested that the cerebral vascular permeability dysfunction occurring in acute arterial hypertension was caused by the increased intraluminal pressure. The aim of the present experiments was to study further this effect on the blood‐brain barrier. To rule out any ischemic influence cerebral vasodilatation was brought about by papaverine injection or CO2 inhalation and the cerebral blood flow measured and shown to be above normal before the blood pressure rise was induced. A sudden elevation of the systemic blood pressure still resulted in increased cerebral permeability indicated by Evans Blue extravasation. In one dog it was shown that an extremely rapid intracarotid autotransfusion resulted in a marked increase in the cerebral venous pressure and small areas of Evans Blue extravasation. Our results support the hypothesis that the permeability changes were caused by the increased intraluminal pressure.