A Comparative Study of the Ototoxicity of Gentamicin and Gentamicin C1
- 1 January 1980
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 106 (1) , 44-49
- https://doi.org/10.1001/archotol.1980.00790250046009
Abstract
• Dose-response experiments comparing the ototoxic liability of the aminoglycoside antibiotics gentamicin sulfate and gentamicin C1sulfate were conducted on guinea pigs. Measures of cochlear electrophysiology, histology, and the pharmacokinetic disposition of the drugs in the plasma and perilymph were made. Electrophysiological and histological measures indicated that gentamicin is more ototoxic than is gentamicin C1. (Arch Otolaryngol106:44-49, 1980)This publication has 6 references indexed in Scilit:
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