Frequency and Prognosis of Coexisting Sickle Cell Disease and Acute Leukemia in Children

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Abstract
Among 58 black children with leukemia, seven had sickle cell trait and one was homozygous for Hb-S. Both of these rates are similar to those for the black population of the United States in general. The presence of sickle cell trait did not appear to influence the median age of onset, the median survival time, or the quality of survival in black children with acute leukemia. The single patient with sickle cell ane mia died a sudden, unexpected death with massive intravascular eryth rocytic sickling secondary to viremia while in a leukemic remission.