Respiratory Function of Hemoglobin

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Abstract
Hemoglobin is essential for oxygen transport, and the study of its structure and function has led to numerous discoveries that have shaped modern biologic science.1 This review will examine how hemoglobin actively regulates oxygen transport and will illustrate the clinical and physiologic importance of this regulation.Oxyhemoglobin Dissociation CurveThe oxyhemoglobin dissociation curve describes the relation between the oxygen saturation or content of hemoglobin and the oxygen tension at equilibrium. Bohr2,3 first showed that the dissociation curve was sigmoid-shaped, leading Hill4 to postulate that there were multiple oxygen-binding sites on hemoglobin and to derive an empirical approximation of the . . .