Detection of Primary Lung Tumors in Rodents by Magnetic Resonance Imaging
- 15 April 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 64 (8) , 2740-2742
- https://doi.org/10.1158/0008-5472.can-03-3258
Abstract
This report describes recent efforts to develop and apply small animal magnetic resonance imaging methods to the study of lung tumors in mice. Magnetic resonance (MR) images obtained with respiratory gating, with data collection synchronized with the respiration of the animal, allow visualization of submillimeter tumors in animals treated with a lung carcinogen. Comparison of the MR images with gross pathology of these lungs demonstrates the utility of the imaging methods for measuring tumor burden. As a noninvasive imaging modality that uses nonionizing radiation, MR is well suited to longitudinal studies aimed at understanding the factors that control the onset and development of lung tumors and their response to therapy in a wide variety of animal models.Keywords
This publication has 7 references indexed in Scilit:
- Recent Advances in Imaging the Lungs of Intact Small AnimalsAmerican Journal of Respiratory Cell and Molecular Biology, 2004
- Respiratory gating for MRI and MRS in rodentsPublished by Institute of Electrical and Electronics Engineers (IEEE) ,2003
- Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/ArfOncogene, 2003
- Molecular Genetics of Lung CancerAnnual Review of Medicine, 2003
- Focus on lung cancerPublished by Elsevier ,2002
- Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genesGenes & Development, 2001
- PRECLINICAL AND CLINICAL MODELS OF LUNG CANCER CHEMOPREVENTIONHematology/Oncology Clinics of North America, 1998