MOLD METABOLITES: 2. THE STRUCTURE OF GRISEOVIRIDIN

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Abstract
By a combination of selectively reductive and hydrolytic processes the structure of perhydrodethiogriseoviridin diacetate, obtained by Raney nickel reduction of griseoviridin diacetate, has been shown to be that of a macrocyclic lactonic peptide (III). Other hydrolytic and degradative experiments have ascertained the points of attachment of the cysteine moiety and the disposition of the functional groups in the aminodecanoic acid. The remaining three carbon atoms have been shown to be part of an unusual dehydro amino acid fragment, and the totality of this and other evidence has defined the structure of griseoviridin as represented in (XXVII).