Tapetoretinal degeneration in the cerebro-hepato-renal (Zellweger's) syndrome.
Open Access
- 1 July 1982
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 66 (7) , 422-431
- https://doi.org/10.1136/bjo.66.7.422
Abstract
Electrophysiological and histopathological study of a baby suffering from Zellweger's syndrome and presenting progressive retinal dysfunction showed this to be related to degenerative changes in the photoreceptor cells and pigment epithelium and to defective myelination of the optic nerve. Disturbances of bile acid and lysine metabolism were also demonstrated, lending support to the concept that Zellweger's syndrome is attributable to a widespread inadequacy of intracellular oxidative function.This publication has 29 references indexed in Scilit:
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