Population Genetics of the Globin Genes in Polynesians
- 1 January 1988
- journal article
- Published by Taylor & Francis in Hemoglobin
- Vol. 12 (5-6) , 533-537
- https://doi.org/10.3109/03630268808991642
Abstract
Globin gene mapping data enable Polynesians to be divided into three distinct groups: (i) Maoris, Cook Islanders, (ii) Tongans, Samoans, (iii) Niue Islanders. Unusual RFLPs detected by the restriction enzymes Apa I and Bgl II are found in Polynesians. A high frequency of alpha-thalassemia in this population is explained by genetic drift and a founder effect.Keywords
This publication has 5 references indexed in Scilit:
- Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.Proceedings of the National Academy of Sciences, 1986
- High frequencies of α-thalassaemia are the result of natural selection by malariaNature, 1986
- α Globin gene rearrangements in polynesians are not associated with malariaAmerican Journal of Hematology, 1985
- Independent recombination events between the duplicated human α globin genes; implications for their concerted evolutionNucleic Acids Research, 1984
- The Molecular Genetics of Human HemoglobinProgress in Nucleic Acid Research and Molecular Biology, 1984