Structure-activity relationships of nogalamycin analogs
- 1 May 1982
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 25 (5) , 560-567
- https://doi.org/10.1021/jm00347a016
Abstract
Nogalamycin (1) has been modified by changes at C-10 and C-7 and in the dimethylamino group to prepare an extensive series of analogues. The chemistry involved in the modifications and structure--activity relationships among these nogalamycin analogues are discussed, as well as comparisons with previously reported compounds 1, 7-con-O-methylnogarol (2), and disnogamycin (11).Keywords
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