Familial Gastroesophageal Reflux and Development of Barrett's Esophagus
- 1 July 1985
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 103 (1) , 52-54
- https://doi.org/10.7326/0003-4819-103-1-52
Abstract
The family of an elderly man with Barrett''s esophagus was examined for gastroesophageal reflux and development of Barrett''s esophagus. All 5 living children have gastroesophageal reflux or esophagitis, or both, and 3 have unequivocal Barrett''s esophagus. Two 3rd-generation descendents have gastroesophageal reflux. This pattern suggests autosomal dominant transmission of the gastroesophageal reflux trait. The family also has a high prevalence of cancer, which may represent the cancer family syndrome.Keywords
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