S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
Top Cited Papers
- 1 April 2004
- journal article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 24 (8) , 3112-3124
- https://doi.org/10.1128/mcb.24.8.3112-3124.2004
Abstract
Read the full review for this F1000Prime recommended article: S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.Keywords
This publication has 66 references indexed in Scilit:
- Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2Genes & Development, 2003
- The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) MotifJournal of Biological Chemistry, 2003
- Protein Kinase C Phosphorylates Ribosomal Protein S6 Kinase βII and Regulates Its Subcellular LocalizationMolecular and Cellular Biology, 2003
- Transduction of Growth or Mitogenic Signals into Translational Activation of TOP mRNAs Is Fully Reliant on the Phosphatidylinositol 3-Kinase-Mediated Pathway but Requires neither S6K1 nor rpS6 PhosphorylationMolecular and Cellular Biology, 2002
- Nerve Growth Factor Specifically Stimulates Translation of Eukaryotic Elongation Factor 1A-1 (eEF1A-1) mRNA by Recruitment to Polyribosomes in PC12 CellsJournal of Biological Chemistry, 2002
- Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase PathwayPublished by Elsevier ,2001
- Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); A novel nuclear target of AktOncogene, 1999
- Characterization of S6K2, a novel kinase homologous to S6K1Oncogene, 1999
- Cloning and Characterization of p70S6KβDefines a Novel Family of p70 S6 KinasesBiochemical and Biophysical Research Communications, 1998
- Comparison of the specificities of p70 S6 kinase and MAPKAP kinase‐1 identifies a relatively specific substrate for p70 S6 kinase: the N‐terminal kinase domain of MAPKAP kinase‐1 is essential for peptide phosphorylationFEBS Letters, 1995