Lipide Changes in Chylomicra and Subnatant Fractions of Rat Lymph During Cholesterol Absorption.

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Abstract
Changes in the distribution of neutral fat, phospholipid and cholesterol between chylomicron and subnatant fractions of rat lymph were produced by feeding emulsions containing cholesterol, fatty acid, triglyceride and taurocholate in various combinations to lymph-fistula rats. Increases in neutral fat were carried largely in the chylomicron fraction, while increases in cholesterol were carried largely in the subnatant fraction. The emulsions also produced changes in the percentage composition of the lipid mixture in each fraction. It is suggested that the chylomicrons are not the sole mechanism for lymphatic transport of either absorbed fatty acid or cholesterol. The data also indicated that the fatty acids of triglycerides are not quantitatively equivalent to free fatty acids in promoting cholesterol absorption.

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