Post-Column Reaction Detection Systems in HPLC

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Abstract
Designs of post-column reaction detection systems for HPLC are discussed with respect to their effect on sensitivity and resolution on the basis of systems theory. The most promising post-column reactor types are the packed-bed reactor and the electronically desegmented liquid-segmented reactor. No experimental data on the latter are available, however. The choice of post-column reaction detector system is greatly influenced by the reaction type. An overview of these reaction types with suggested systems are given. For two examples, corticorsteroids and catecholamines in plasma, a comparison is made of the different detection possibilities.