Many authors have considered that there is a relationship between scleroderma and endocrine disorders of various kinds; in fact, every one of the endocrine glands has been mentioned in association with scleroderma. It seems to be a fact that many patients have shown great improvement while receiving thyroid therapy, and it is reasonable to believe that if the metabolism is low thyroid may be of use. Since, however, as many cases of scleroderma have been reported in association with hyperthyroidism as in association with hypothyroidism it is evident that deficiency of thyroid cannot account for the condition in all cases. In a case of diffuse scleroderma in a child of 9 years Goodman1 reported recovery with administration of desiccated thyroid. Apert and Leblanc2 described a case of generalized scleroderma with improvement following the use of desiccated thyroid. Roesch3 reported a case of generalized scleroderma in