Synthesis of Atropisomeric Biphenylbisphosphine, 6,2′-Bis(diphenylphosphino)-3-methoxy-2, 4-dimethyl-4′,6′-bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and Its Use in Ruthenium(II) -Catalyzed Asymmetric Hydrogenation of a 3-Oxo Ester1
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (11) , 827-829
- https://doi.org/10.1055/s-1991-20893
Abstract
New atropisomeric biphenylbisphosphines, 6,2′ -bis(diphenylphosphino)-3-methoxy-2, 4-dimethyl-4′,6′ -bis(trifluoromethyl)-1,1′-biphenyl (FUPMOP) and 2,2′-bis(diphenylphoshino)-4,6,4′,6′-tetrakis(trifluoromethyl)-1, 1′-biphenyl (BIFUP), have been prepared from 2-bromo-3, 5-bis(trifluoromethyl)nitrobenzene. The FUPMOP-ruthenium(II) complex proved to be an excellent catalyst for the asymmetric hydrogenation of methyl 3-oxobutanoate.Keywords
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