Alleviation of Cobalt Toxicity in Calves by Methionine Administration

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Abstract
Calves were able to tolerate intravenous injections of small doses of cobalt without symptoms of toxicity. Larger doses of cobalt sulfate (0.3 mg. of cobalt per pound of body weight or more) caused symptoms of toxicity which were lacrimation, salivation, dyspnea, incoordination, defecation and urination. The injection of methionine previous to the injection of cobalt prevented or markedly reduced the severity of these toxicity symptoms. The lethal dose of cobalt injected intravenously is more than 4 mg. per pound of body weight for the dairy calf. Copyright © . .

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