Dual Functions of Yeast tRNA Ligase in the Unfolded Protein Response: Unconventional Cytoplasmic Splicing ofHAC1Pre-mRNA Is Not Sufficient to Release Translational Attenuation
Open Access
- 1 November 2010
- journal article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 21 (21) , 3722-3734
- https://doi.org/10.1091/mbc.e10-08-0693
Abstract
Unconventional cytoplasmic splicing of HAC1 mRNA is essential for the yeast unfolded protein response (UPR). The UPR requires translational regulation of unspliced and spliced forms of HAC1 mRNAs. ... The unfolded protein response (UPR) is an essential signal transduction to cope with protein-folding stress in the endoplasmic reticulum. In the yeast UPR, the unconventional splicing of HAC1 mRNA ...Keywords
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