THE EFFECTS OF EXTRACTS OF TESTIS IN CORRECTING THE CASTRATED CONDITION IN THE FOWL AND IN THE MAMMAL*†

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Abstract
Lipid extracts of bull testes have yielded the active principle, or principles, of the internal secretion of the testis. Methods of detecting the active principle have been (1) the growth of the capon comb, wattles and ear lobes; (2) the spermatozoon motility test (guinea pig); (3) the electric ejaculation test (guinea pig);(4) the prostate gland cytology test (rat); (5) the seminal vesicle cytology test (rat). All tests provide a rapid indicator for castration and all castration changes have been prevented from appearing by daily injections of the hormone preparations; also, if castration changes are permitted to develop before beginning injection of the testis extract, the animals (bird and mammal) can be restored to the normal state within short periods by injecting the same preparation. Injections must be continuous. A daily dose of 0.01 mgm. of active material per capon per day causes distinct comb growth.