ACRIFLAVINE RESISTANCE: A BACTERIOPHAGE MUTATION AFFECTING THE UPTAKE OF DYE BY THE INFECTED BACTERIAL CELLS
- 1 January 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 53 (1) , 24-30
- https://doi.org/10.1073/pnas.53.1.24
Abstract
Experiments on the uptake of acriflavine by uninfected E. coli cells and by cells infected with acridine-sensitive or -resistant bacteriophage show that (1) sensitivity to acriflavine is related to a greatly increased uptake of dye by infected cells; (2) one of the two mutations to acridine resistance in bacteriophage T2 and T4 results in a reduced uptake of dye; and (3) the process responsible for increased acriflavine uptake is dependent on phage-direct protein synthesis in the infected cells.Keywords
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