Homology among DNA-binding proteins suggests use of a conserved super-secondary structure
- 1 July 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 298 (5873) , 447-451
- https://doi.org/10.1038/298447a0
Abstract
The amino acid sequences of the repressor and cro proteins of phages λ, 434 and P22 are homologous, especially in a region in which repressor and λ cro have a similar α-helix–turn–α-helix secondary structure. Model-building studies indicate that this structure is important in DNA binding, and we suggest it may be a common feature of many DNA-binding proteins.This publication has 45 references indexed in Scilit:
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