Proguanil-resistant Falciparum Malaria
- 21 January 1950
- Vol. 1 (4646) , 147-151
- https://doi.org/10.1136/bmj.1.4646.147
Abstract
Use of Proguanil (paludrine) as a suppressive for malaria was begun in the rubber estates of Malaya in 1947, large numbers of the workers receiving small daily doses as a suppressive. By the end of 1948 strains of P. falciparum were appearing which were resistant to small doses; in 1949 cases appeared which were resistant to large doses. The emergence of resistant strains may be related to the widespread employment of the drug for suppression. These observations confirm the exptl. results with P. gallinaceum and P. cynomologi.Keywords
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