Dogs were prepd. with complete pyloric occlusion and gastric-duodenal and gastrio-antral fistulas, using brass cannulae. Tygon tubing connected these cannulae, producing an external gastroenterostomy, through which food passed from the stomach to the intestine. Disconnection of the tubing created a total stomach pouch. The gastric secretory response to histamine was 50-100% greater in these animals than in total pouches with intact vagus nerves, prepd. as described by Dragstedt. Comparative studies showed the following maximal gastric secretory response to one injection of 0.6 mg. of histamine base over a 90-min. period, for the total pouch 150 ml. of gastric juice containing 21 mEq. of HC1; for the gastric-duodenal fistula, 299 ml. with 42 mEq.of HC1 and for the gastric-antral fistula 347 ml. with 49 mEq. of HC1. Mortality rates were lower, the length of survival was longer, and the nutritional state was superior in these animals, as compared with total gastric pouches with intact vagus nerves. These prepns. permit the stomach to remain an integral part of the digestive system, except during expts.