Effect of b‐itc1‐site inhibitors on the midpoint potentials of mitochondrial cytochromes b
- 8 May 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 155 (2) , 237-240
- https://doi.org/10.1016/0014-5793(82)80611-x
Abstract
Anaerobic potentiometric titrations of b cytochromes have been carried out in beef heart submitochondrial particles in the presence of several specific inhibitors of electron transfer through the b‐c 1‐site of the respiratory chain. Whereas antimycin shows no significant effect on the titration curve of cytochrome b‐562, NoHOQnO is found to shift the E m of b‐562 by 20–30 mV to the positive. Funiculosin raises the E m of b‐562 by > 100 mV and also appears to bring about a minor shift of b‐566 midpoint potential. In the presence of myxothiazol, both b cytochromes with E m values 15–30 mV more positive than in the control.Keywords
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