High-Yielding Staudinger Ligation of a Phosphinothioester and Azide To Form a Peptide
- 19 December 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (1) , 9-12
- https://doi.org/10.1021/ol006739v
Abstract
The Staudinger ligation can be used to couple a peptide with a C-terminal phosphinothioester to another with an N-terminal α-azido group to form a single peptide that contains no residual atoms. Here, diphenylphosphinomethanethiol thioesters are shown to give high isolated yields for this transformation. This finding provides precedent for a powerful and versatile new method for the total synthesis of proteins.Keywords
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