Incidence of chromosome 21 disomy in human spermatozoa as determined by fluorescent in-situ hybridization
Open Access
- 1 April 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 11 (4) , 722-726
- https://doi.org/10.1093/oxfordjournals.humrep.a019241
Abstract
We have evaluated the incidence of chromosome 21 disomy in decondensed sperm heads from nine normal men using a locus-specific DNA probe for chromosome 21, and a centromeric probe for chromosome 6 as a control. The results show that the incidence of chromosome 21 disomy (0.38%) is significantly higher than disomy for chromosome 6 (0.14%). No differences were found among the individuals analysed.Keywords
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