Syntheses of 1-trifluoromethyl-2-naphthalenols via a novel construction of the naphthalene nucleus
- 1 February 1983
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 61 (2) , 368-371
- https://doi.org/10.1139/v83-066
Abstract
A relatively simple and efficient synthesis of the hitherto unknown 1-trifluoromethyl-2-naphthalenols is described. Easily accessible benzenoid precursors 6 and 7 were converted to the oximino-ketones 8 and 9 by nitrosation. A novel cyclization and hydrolysis afforded surprisingly stable hydroxytetralones 12 and 13 which in turn were aromatized to the naphthalenols 1 and 15.This publication has 1 reference indexed in Scilit:
- Studies on organic fluorine compounds. Part 35. Trifluoromethylation of pyrimidine- and purine-nucleosides with trifluoromethyl–copper complexJournal of the Chemical Society, Perkin Transactions 1, 1980