Tissue Sites of Alpha1 Fetoprotein Synthesis by the Rat During Pregnancy and Hepatoma Growth 2

1 March 1976

journal article
research article
Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute

Vol. 56 (3) , 645-648
https://doi.org/10.1093/jnci/56.3.645

Abstract

The tissue sites of alphal fetoprotein (AFP) synthesis by the rat during gestation and hepatoma growth were determined by specific incorporation of a radiolabeled amino acid precursor into AFP by tissue cultures in vitro. During gestation, AFP were produced by the yolk sac, the fetal liver, and in small amounts by the fetal gastrointestinal tract; there was no synthesis by maternal rat tissues. During growth of a transplantable hepatoma, only the hepatoma tissue synthesized AFP; the nontumor tissue of the host contained AFP but did not produce it.

Keywords

This publication has 1 reference indexed in Scilit:

Embryonal serum α‐globulin in cancer patients: Diagnostic value
International Journal of Cancer, 1967