Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium
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Open Access
- 15 April 2008
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 111 (8) , 4029-4038
- https://doi.org/10.1182/blood-2007-10-119974
Abstract
Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis.Keywords
This publication has 52 references indexed in Scilit:
- Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)Blood, 2007
- Autoimmune diseases, asthma and risk of haematological malignancies: A nationwide case-control study in SwedenEuropean Journal Of Cancer, 2006
- European multi-centre study on coeliac disease and non-Hodgkin lymphomaEuropean Journal of Gastroenterology & Hepatology, 2006
- Risk of haematopoietic cancer in patients with inflammatory bowel diseaseGut, 2005
- Medical history and risk for lymphoma: results of a population-based case-control study in GermanyEuropean Journal Of Cancer, 2005
- Extrasalivary lymphoma development in Sjögren's syndrome: Clonal evolution from parotid gland lymphoproliferation and role of local triggeringArthritis & Rheumatism, 2003
- Evolving concepts of rheumatoid arthritisNature, 2003
- Quantifying heterogeneity in a meta‐analysisStatistics in Medicine, 2002
- Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphomaThe Lancet, 2000
- Malignant Lymphoma of the Thyroid GlandThe American Journal of Surgical Pathology, 2000