Long-term treatment of rheumatoid arthritis with tumour necrosis factor blockade: outcome of ceasing and restarting biologicals

Abstract
Sir, Infliximab, a chimeric monoclonal antibody, has demonstrated effective suppression of disease and prevention of the progression of structural damage in rheumatoid arthritis (RA) in its phase III randomized study (ATTRACT study) [1, 2]. Two anti-tumour-necrosis factor α (TNF-α) drugs, infliximab and etanercept, have recently been approved by the National Institute of Clinical Excellence [3].

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