Cerebrospinal Fluid Clearance of Choline and Some Other Amines

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Abstract
The elimination from CSF of the quaternary ammonium compounds choline, methylatropine and decamethonium and the tertiary amine atropine has been investigated by ventriculo‐cisternal perfusion in anesthetized dogs and rabbits. The elimination of the amines from the perfusate was partly concentration dependent. Further, in the rabbit experiments they decreased the elimination of each other. In the dog 63 per cent of the infused choline was eliminated between the lateral ventricle and cisterna magna at an infusate concentration of 5·10‐‐6M and a rate of 150 μl/min. The corresponding figure for the rabbit was 78 per cent at 30 μl/min. Brain drug concentrations after the experiments revealed that diffusion into the brain contributed to the elimination only to a minor extent. Results were compared to invitrostudies on choroid plexa. A correlation was found between the rate of removal from perfusate for the quaternary drugs and their uptake characteristicsin vitro. The conclusion was drawn that the investigated amines are eliminated from CSF partly by a carrier mediated process. One important site of this process is probably the choroid plexus.