DURATION OF THE HYPOTENSIVE EFFECT OF GUANFACINE

1 January 1982

journal article
research article

Vol. 20 (4) , 174-178

Abstract

Guanfacine given i.v. to patients caused a brief rise in blood pressure. This was followed by a sustained decrease of blood pressure, accompanied in 1 case by a marked orthostatic effect. In addition to its lowering effect on blood pressure, guanfacine also reduced heart rate. The duration of action for up to 72 h was due to the long half-life of the drug. The main side effects observed were fatigue and sedation.

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