Genetics and the Specificity of the Aging Process
- 28 February 2003
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 299 (5611) , 1351-1354
- https://doi.org/10.1126/science.1082358
Abstract
The identification and study of long-lived mutant animals has provided valuable insights into the mechanisms that limit the life-span of organisms. Findings with the gene SIR2 suggest that the rate of aging can be regulated under certain conditions. Indeed, increased expression of SIR2 lengthens life-span by acting on biological processes that promote survival under conditions of scarcity. In addition, studies of mutant strains of Caenorhabditis elegans , in particular daf-2 , clk-1 , and isp-1 mutants, suggest that the biology of reactive oxygen species in the mitochondria and elsewhere might be the main determinant of life-span in this organism. Thus, the aging process may be more specific than previously anticipated on evolutionary grounds.Keywords
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