Cardiac drift during prolonged exercise with echocardiographic evidence of reduced diastolic function of the heart

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Abstract
This study examined whether, in 16 male subjects, a continuous increase in heart rate (HR) during 4 h of ergometry cycling relates to cardiac fatigue or cardiomyocyte damage. Serum cardiac troponin T (cTnT) was determined and echocardiographic assessment was carried out prior to and after 2 h of exercise, within 15 min of completing exercise and after 24 h. Left ventricular contractile function (end-systolic blood pressure–volume relationship [SBP/ESV]) and diastolic filling (ratio of early to late peak left ventricular filling velocities [E:A]) were calculated. During exercise HR was 132±5 beats min−1 after 2 h and increased to 141±5 beats min−1 (mean ± SD; P−1 to 36.5±5.2 mmHg cm−1 and SBP/ESV was not correlated to maximal oxygen uptake (r2=0.363). In contrast, E:A decreased (1.82±0.32 to 1.48±0.30; Pr2=0.61; P<0.05). Low levels of cTnT were detected in two subjects after 4 h of exercise that had normalised by 24 h of recovery. During prolonged exercise cardiovascular drift occurred with echocardiographic signs of a reduced diastolic function of the heart, especially in those subjects with a high maximal oxygen uptake.