Abstract
The relationship between prolactin-thyroxine antagonism and the metamorphosis of visual pigments in larval amphibians has been investigated using bullfrog (Rana catesbeiana) tadpoles. Although prolactin-thyroxine antagonism is demonstrable by morphological criteria, ovine prolactin does not appear to antagonize thyroxine-induced rhodopsin synthesis. The hypothesis is offered that prolactin-thyroxine antagonism is the result of differential gene activities which are opposite in their physiological effects.