A COMPARISON OF THE ANTIFERTILITY EFFECTS OF ALKYLATING AGENTS AND VINCA ALKALOIDS IN MALE RATS

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Abstract
The anti‐fertility effects of cyclophosphamide, nitrogen mustard, vincristine and vinblastine were studied and compared in male rats. The effects of the drugs on body weight and haematological values were used to monitor the pharmacological actions of the drugs. All four drugs impaired fertility, the severity of the impairment depending on dose and duration of treatment. Testicular size and histological appearances remained mostly normal, even in infertile animals, but seminiferous tubules were fewer in number and maturation arrest at the spermatid level was evident in some sections. Recovery of drug‐induced infertility occurred in 64% of treated animals, 9 to 40 weeks after cessation of treatment. Morbidity and mortality were much higher with alkylating agents than with vinca alkaloids for approximately similar degrees of impairment in fertility.

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