Lanthanide complexes of a cyclen derivative with phenylphosphinic pendant arms for possible 1H and 31P MRI temperature sensitive probes
- 1 January 1999
- journal article
- Published by Royal Society of Chemistry (RSC) in New Journal of Chemistry
- Vol. 23 (12) , 1129-1132
- https://doi.org/10.1039/a904656i
Abstract
Lanthanide complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis[methylene(phenylphosphinic) acid] (H4L) were found to give a linear correlation of 1H and 31P NMR chemical shifts to temperature in the physiologically relevant temperature range, with dependencies comparable or better than those found for existing complexes; due to the greater hydrophobic character of the ligand the complexes may exhibit a different biodistribution in the body.Keywords
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