Activity of Microsomal Heme Oxygenase in Liver and Spleen of Ascorbic Acid-Deficient Guinea Pigs
- 1 January 1980
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 361 (2) , 1243-1250
- https://doi.org/10.1515/bchm2.1980.361.2.1243
Abstract
Hepatic heme oxygenase activity was significantly altered in vitamin C-deficient guinea pigs. It was increased 2-fold after 14 days and decreased by 20% after 21 days of deprivation of the vitamin (always in comparison with the control value). The apparent Km of the enzyme was altered in the course of ascorbic acid deficiency. The data of hepatic heme oxygenase activity correpond to previous results on the metabolism of hepatic cytochrome P-450 in different stages of ascorbic acid deprivation. Splenic heme oxygenase activity decreased progressively, arriving at 50% of the control value after 21 days of vitamin C omission; its apparent Km remained unaltered.This publication has 15 references indexed in Scilit:
- Activity of Microsomal Heme Oxygenase in Liver and Spleen of Ascorbic Acid-Deficient Guinea PigsHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1980
- Induction of hepatic heme oxygenase activity by bromobenzeneArchives of Biochemistry and Biophysics, 1979
- Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activityArchives of Biochemistry and Biophysics, 1976
- ASCORBIC ACID AND CYTOCHROMESAnnals of the New York Academy of Sciences, 1975
- The effect of phenobarbital, 3-methylcholanthrene, 3,4-benzpyrene, and pregnenolone-16α-carbonitrile on microsomal heme oxygenase and splenic cytochrome P-450Archives of Biochemistry and Biophysics, 1974
- Abnahmen der Cytochromgehalte und Veränderungen der Kinetik der Monooxygenase in Lebermikrosomen von Meerschweinchen bei verschiedenen Stadien des AscorbinsäuremangelsHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1972
- Änderungen im Gehalt der Phospholipoide von Lebermikrosomen unterschiedlich vorbehandelter Ratten und MeerschweinchenHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1970
- Untersuchungen zur scheinbaren Michaelis-Konstante von Acetanilid bei dessen p-Hydroxylierung in Lebermikrosomen skorbutischer MeerschweinchenHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1970
- The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.Proceedings of the National Academy of Sciences, 1968
- ENZYME-STRUCTURE RELATIONSHIPS IN THE ENDOPLASMIC RETICULUM OF RAT LIVERThe Journal of cell biology, 1962