Loloatins A−D, Cyclic Decapeptide Antibiotics Produced in Culture by a Tropical Marine Bacterium

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Abstract
Loloatins A (1) to D (4), a family of new cyclic decapeptide antibiotics, have been isolated from laboratory cultures of a tropical marine bacterium recovered from the Great Barrier Reef in Papua New Guinea. The structures of loloatins A−D were elucidated via a combination of spectroscopic analyses and chemical degradation. Loloatins A−D exhibit in vitro antimicrobial activity against methicillin-resistant Staphyloccoccus aureus, vancomycin-resistant enterococci, and drug-resistant Streptococcus pneumoniae.