MIGRAINE

13 December 1930

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 95 (24) , 1825-1828
https://doi.org/10.1001/jama.1930.02720240035010

Abstract

Early in my experience with the ketogenic diet,¹it was tried in cases of migraine. Since then Lennox and Cobb,²in their monograph on epilepsy, have stated that it would be of interest to know whether the induction of acidosis is of benefit in cases of migraine. Since the original report from the Mayo Clinic,³Schnabel⁴has reported his experience with a ketogenic diet in cases of migraine. Some of the recent etiologic theories and therapeutic suggestions are of interest in considering the justification of a ketogenic regimen in cases of migraine. R. and S. Weissmann-Netter⁵found apparent changes in the acid-base balance: the hydrogen ion concentration and alkali reserve are normal in the periods of freedom from attacks but a tendency to alkalosis develops forty-eight hours prior to an attack. The recent method of studying acid-base equilibrium by hyperpnea or overventilation of the lungs,

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