Hemoglobin S Travis: a Sickling Hemoglobin with Two Amino Acid Substitutions [β6(A3)Glutamic Acid → Valine and β 142(H20) Alanine → Valine]
Open Access
- 1 August 1977
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 77 (3) , 561-566
- https://doi.org/10.1111/j.1432-1033.1977.tb11699.x
Abstract
The .beta.6 Glu .fwdarw. Val mutation imparts to Hb S Travis the characteristic properties of sickling Hb, namely its association with erythrocyte sickling, the insolubility of the Hb in the reduced form, and a minimum gelling concentration value identical to Hb S. Unlike Hb S, Hb S Travis exhibits an increased O2 affinity and a decreased affinity for 2,3-bisphosphoglycerate and inositol hexakisphosphate. In addition, the variant Hb tendency to autoxidize and its mechanical precipitability suggest that there are conformational differences between Hb S and Hb S Travis.This publication has 28 references indexed in Scilit:
- Hemoglobin C Ziguinchor αA2β62 (A3)Glu → Val β58(E2)→ Arg: The second sickling variant with amino acid substitutions in 2 residues of the β polypeptide chainFEBS Letters, 1975
- Hemoglobin Syracuse (alpha2beta2-143(H21)His leads to Pro), a new high-affinity variant detected by special electrophoretic methods. Observations on the auto-oxidation of normal and variant hemoglobins.Journal of Clinical Investigation, 1975
- X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human DeoxyhaemoglobinNature, 1972
- Demonstration of a simple method for reducing losses of tryptic peptides during automated sequencingBiochemical and Biophysical Research Communications, 1972
- Ligand-induced conformational dependence of hemoglobin in sickling interactionsJournal of Molecular Biology, 1971
- Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of AllosteryNature, 1970
- Three-dimensional Fourier Synthesis of Horse Oxyhaemoglobin at 2.8 Å Resolution: The Atomic ModelNature, 1968
- Abnormal human haemoglobins: Separation and characterization of the α and β chains by chromatography, and the determination of two new variants, Hb chesapeake and Hb J (Bangkok)Journal of Molecular Biology, 1966
- Tryptic cleavage at cysteinyl peptide bondsBiochemical and Biophysical Research Communications, 1963
- SULFHYDRYL GROUPS AND THE STRUCTURE OF HEMOGLOBINThe Journal of general physiology, 1956