ANEMIA OF INFLAMMATORY DISEASE IN THE DOG - FERROKINETICS OF ADJUVANT-INDUCED ANEMIA

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Abstract
Anemia of inflammatory disease induced by adjuvant injection was characterized by decreases in hematocrit (mean .+-. 1 SD, 37.5 .+-. 2.7%, as compared with baseline values of 49.8 .+-. 2.4%) and Hb (12.54 .+-. 1.22 g/dl, as compared with a base line of 16.87 .+-. 0.96 g/dl) and was classified as unresponsive, normocytic and normochromic. Disordered Fe metabolism was manifest by decreases in serum Fe (62.3 .+-. 13.6 g/dl, as compared with a base line of 113.0 .+-. 8.2 g/dl) and shortened mean radio-Fe clearance half-times [t1/2](50.0 .+-. 12.6 min, as compared with a base line of 74.0 .+-. 13.6 min) in the presence of increased bone marrow reticuloendothelial Fe. Shortened radio-Fe clearance t1/2 reflected maximal Fe extraction from the plasma by the erythroid marrow due to suboptimal Fe supply, since Fe extraction by other tissues is minor. Shortened mean marrow transit times (2.79 .+-. 0.46 days, as compared with a base line of 5.4 .+-. 0.64 days) were indicative of adequate erythropoietin stimulation in the anemia of inflammatory disease. Increases in plasma Fe turnover rate over base line (1.73 .+-. 0.33 mg/dl per day to 1.51 .+-. 0.34 mg/dl per day), erythron Fe turnover rate (1.50 .+-. 0.27 mg/dl per day, as compared with a base line of 0.99 .+-. 0.27 mg/dl per day), and erythrocyte Fe utilization (86 .+-. 8.3%, as compared with baseline utilization of 65 .+-. 9.3%) indicated that erythroid marrow proliferation was effective. The magnitude of erythroid response appeared to be limited mainly by Fe supply.

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